TMH/TMH/2025-26/CAP/EO/0013

Model Name:

Year of Introduction:

Year of Probable end of support:

Country of Origin :

GTE Availability: Yes, at Sr no. 88 as 'NextGen Sequencing Machine for DNA/RNA'

Please quote the model which is including the latest state of art equipment and meets the required specifications. The quoted model should be latest introduced with end of support not before 10 years from the date of installation at TMC.

System should occupy minimal lab footprint and should be capable of performing template RNA/DNA amplification, sequencing and primary analysis.

The sequencing chemistry should mimic natural biological chemistry with sequential or simultaneous addition of all four bases in the sequencing reaction for competitive addition to the RNA/ DNA template. The chemistry should thus allow for highly accurate sequencing through homopolymeric regions.

Seqeuncing workflow should be simple with faster data analysis and should include end-to-end solution from base calls to variants

System should use dedicated reagents for generating data of 25 Gb or more and 25 million reads or more. The output should be scalable depending on requirements.

Sequence output should generate accurate base calls and high error free reads with >99% raw read accuracy.

Quoted system should provide automated Template amplification .

The system should be offered with single end or paired-end chemistry.

The sequencer should facilitate New Pathogen discovery and genome analysis (Bacteria, Viruses, Fungi, parasites)

Should have kits for detection of viruses, bacteria, fungi resistant geners from all types of samples

Primary and secondary softwares should be provided with multiple user access

System should identify rare and novel pathogens & genotypes

Multiple user access and utilization without affecting operational efficiency

Comprehensive data analysis options, especially a secure cloud-based platform for data management, storage, and analysis.

The system should have an option of integrating with a cloud based computing environment, for data storage, sharing and analysis.

The sequencing chemistry should be robust and globally proven, demonstrated with abundant peer reviewed publications.

System should offer the user-friendly sequencing experience, such as, intuitive touchscreen user interface, RFID tracking and pre-mixed/pre-filled reagent cartridge for minimal user intervention.

Performance parameter required as below: ( like accuracy, sensitivity, sample volume requirement, resolution or such performance parameters to be highlighted)

Following additional accessoies required to run the system should be provided by the supplier:

Should perform preventive maintenance (2nos) during warranty,AMC,CMC & if entered into AMC(includes unlimited breakdown calls) /CMC (which will include spare replacement, breakdown calls). Vendor to submit SOPs for PMS at the time of installation/ commissioning. This is mandatory requirement.

IQ/OQ/PQ and Calibration/validation of the system is included in the scope of supply. All standards, test samples, other consumables, etc. needed for the same shall be arranged by the supplier/ manufacturing company. IQ/OQ should be done at the time of installation. Proper certifications for NABL accreditation should be provided by the manufacturer/supplier/bidder.

Vendor to submit the technical data sheet, brochure etc as a tender document with reference to the quoted make & model. Please mention the reference page no., quoted model name/number against each item etc in these documents against each technical specifications in the compliance.

Vendor to submit list & cost of consumables/consumable Spares( i.e.spares need to be replaced at regular intervals, maybe quarterly/half yearly/yearly etc.) if any.

Please submit pre installation requirements [electrical, HVAC, Compressed air along with air pressure mentioned), water requirement (RO/DI/Distilled water with its pressure, flow rate per hour) ; if any of the above is essential]

Vendor to provide UPS with adequate capacity, if required for the quoted equipment. If not required, vendor to mention the same.

Vendor to submit details of footprint size & weight of the quoted model.

Vendor to submit power consumption.

Demo of the quoted model , will be required if so desired by the user, after the opening of the technical bid and prior to opening of financial bid. This is for technical evaluation. All technical specifications mentioned above to be mandatorily shown in the demo unit.

User's/Installation list: A list of installations of the quoted model with the address and contact numbers to be provided.

Predispatch inspection at factory will be required if desired by authorities.

Should be CE/US FDA/BIS/ICMED approved.

Vendor should provide the User manual and service manual copy during the installation of the equipment.

Unpacking and shifting the consignment to the installation site is to be included in the vendor's scope of supply. Bidder/manufacturer/authorized service provider should take responsibility to lift /shift the consignment from unloading site to the installation site. Unloading site shall be Stores department, TMH. If needed ,bidder has to arrange for the labours at no charge to TMH.(Before submitting the quotation,bidders may visit TMH to know unloading and installation site.

Training: Operational training to be provided onsite to all departmental staff and primary level maintenance training to be provided to inhouse Biomedical Engineers.

Local Service Support: Should have local office and service support/service engineer for attending the breakdown calls. Details to be submitted.

Response Time: Should not be more than 06 hrs from lodging a breakdown complaint on toll free or by email.

Warranty- 2 years

CMC- cost per annum will be considered for all bidders for 8 years after warranty

Warranty and CMC Should include a) 2 preventive maintenance/ year and unlimited breakdown calls along with spares.b) All bought out items quoted along with the main system (local/non-local) and UPS should be covered. c) Yearly calibration/Validation, Testing and measuring equipment used should be traceable to SI units through National/ International standards (as per NABL/NABH norms). d) PM kit if any. e) All upgrades/update, no seperate licence fees will be payable.

Back to back assurance to be taken by the supplier from OEM to supply spares for minimum 10 years and to be submitted.

Penalty Clause:

1) If 2 years comprehensive warranty and CMC for 8 years after warranty condition is not adhered to, TMC reserves right to reject the offer.

2) Please mention whether UPS is required for the equipment. If so should be included in the offer.

3) Only Yes or No should be mentioned in compliance report and additional information should in remarks column.