MRI 3 TESLA

TATA MEMORIAL CENTRE

CENTRAL PURCHASE UNIT

ADVANCED CENTRE FOR TREATMENT, RESEARCH & EDUCATION IN CANCER

TECHNICAL SPECIFICATION OF :- - "MRI 3 TESLA" Qty-2 Nos. for Radiodiagnosis Dept. ACTREC.

Intended Use: To conduct MRI based imaging studies predominantly for Oncology patients

Sr. No. Name of the Vendor :

I Technical Specifications / Scope of supply COMPLIANCE 1) Mention "Complied /Not Complied" 2) Highlight any deviations. 3) Mention part number/Catalogue number of the relevant item quoted. Remarks

II Name of the Manufacturer :

III Country of Origin:

IV Model Name / Model No. of the Equipment (If the equipment is a combination of more than one equipment then list down the model no. pertaining to each)

V Year of Introduction Internationally

VI Year of Introduction in India

VII Technical Specifications/Scope of supply

VIII Note: All specifications as detailed below should be integral and none of these essential requirements should be quoted as optional.

IX Please quote the latest state of the art model which meets the tender specifications. The offer should be complete in all respect for the intended use. The specifications detailed below should be understood as minimum specification. The quoted model should be latest introduced with end of life or End of Service not before 10 years from the date of installation at TMC.The system should be totally new and should not contain refurbish or having recycled items. Please mark clearly under the compliance column ‘Bidder’s Offer’ that equipment meet the required specifications. Please use the remark column to provide details of the specifications or in case there is any deviations.

X Also, page number of the equipment brochure or product data sheet of technical specifications, if provided, should be clearly mentioned in remark column against each of the required specification.

XI The equipment should be “state of the art” new 3 Tesla MRI system with at least 64 independent channel / channel independent RF receiver channels as per specifications below. The offered model should be US FDA/ European CE/BIS/ICMED approved (authentic and legible certificate for the same to be annexed).Also, the vendor will guarantee that the system supplied is not refurbished and the MR system quoted is the latest best available model in the segment (3T MR scanner with 70 cm or more bore) quoted, at the time of delivery and should submit an undertaking in this regard. The offered model should be the latest and launched after 2015 RSNA. No older models with version improvements are allowed.

XII Features and specifications required:

1 3 Tesla Active shielded super conductive magnet.

2 Length should be short with at least 70cm flared opening.

3 It should have facilities of better illumination, ventilation and designed to avoid patient claustrophobia.

4 The homogeneity of the magnet should be mentioned in relation to 10, 20, 30, 40, and at its highest DSV. Please attach data sheet and method.

5 Magnet should be shielded from external interferences. 5 gauss line should be within the magnet room.

6 Cryogen vessel to be of Helium only with appropriate super thermal shielding and refrigeration facility for minimum Helium boils off.

7 Helium level monitoring equipment of the magnet and facility for appropriate quick shutdown of the magnet in the event of emergency from the console as well as gantry.

8 Liquid Helium Should be supplied during Warranty period and comprehensive AMC

9 Kindly specify where the magnet of vendor is manufactured. If the manufacturing magnet at more than one site then Europe or USA site manufactured magnet should be provided.

1 High performance and highly stable, manual and auto- shimming for high magnetic field for homogeneity imaging for fMRI,MRS,MRSI. Specify time for shimming.

2 Auto shim (global and voxel shim) should take minimum time to shim the magnet with patient in position.

3 Second order/High order shimming/Auto shimming should be offered as standard.

4 Patient specific RF shimming should be provided.

C GRADIENT SYSTEM

1 System should have a minimum gradient strength of 44mT/m at slew rate of at least 200T/m/sec in each axis and this should be achieved with the rise time not more than 250ms. The Gradient and slew rate value nust be actual and should not be compared to 44m/T/m and 200 t/M/s om the basis of equivalent performing TE/TR values.

2 Both Max slew rate and peak amplitude should be achieved.

3 Noise limits / ODI comfort level of the gradients should conform to the standards set by FDA / NEMA / both.

4 The Gradient system should have provision for eddy current compensation.

5 Field of View should be at least 50/50/50cm in all three axis

6 Minimum TE and TR in 2D/3D should be specified in relation to the sequences

7 Minimum Slice Thickness in 2D and 3D should be specified in relation to the sequences.

8 Echo Train length in both Spin echo and Gradient Echo should be at least 256 or more.

9 The measurement matrix should be from 128x128 to 1024x1024 in both 2D and 3D imaging as well.

1 RF system should be fully digital dual RF and solid state with transmit power of at least 30KW or more.

2 The vendor should quote the latest RF transmit technology available with them gobally as per the datasheet.

3 It should also have at least minimum of 32 channel/ channel independent RF channels/ 64 channel with each having bandwidth of 1MHz or more along with necessary hardware to support Quadrature/ CP array coils.

4 It should support Parallel acquisition techniques like K space base (ARC / GRAPPA) and also image based (ASSET/SENSE/IPAT) with a factor of at least 4. Higher factors if available should be offered.

5 Specify frequency stability and amplifier resolution.

6 RF system should be compatible with parallel imaging technique. It should be able to support time reduction with compatible coils in 2D/3D imaging in body / neuro imaging up to acceleration factor of at least 4.

7 Latest RF transmit system (like Multi- transit/ Multi Drive transmit system/ True shape) with at least two independent output channels should be offered to improve B1 uniformity and signal homogeneity and to reduce patient induced in-homogeneities.

8 Latest available gradient noise reduction techniques with hardware and software.

1 The system body Coil integrated to the magnet. In addition to this coil following Coils - should be quoted:

2 Dedicated Head coil – Phased array coil with at least 32 elements/channels or more for cranial application including paediatric head - 1 Qty.

3 Separate coil for Head and Neck atleast 19 channels or more for routine brain/ neurovascular exams should be also be quoted as standard – 1 Qty.

4 Posterior array coil should be integrated on / under table top for thoracic and lumbar spine imaging with at least 24 channels or more with head or feet first without coil handling or repositioning. Posterior coil should combine effortlessly with other coil for large coverage and fast and easy patient coverage. The spine coil should provide complete coverage of brain and spine with combination of coils. Maximum achievable FOV should be mentioned. Tim/ Gem Suite / DStream – 1 Qty.

5 Body array coil with 46 channel or more in a given FOV of 50 cm or better, with combination of coils should be quoted as standard. Please specify all the coils to achieve this. Anterior Phased Array Body coil must be capable of doing whole abdomen and pelvic (prostate, rectum and cervix), MRCP etc. The coil should cover the heart, abdomen and pelvis. Please specify the time reduction factor with PAT

6 Peripheral coil or whole body coil with a coverage of atleast 80cms (with a maximum combination of 2 coils)

7 Dedicated Breast Coil capable of performing simultaneous bilateral breast imaging with minimum of 15 element / channel (even 3rd party coil for particular this region is accepted). Breast coil should have capability to do breast spectroscopy – 1 Qty. This breast coil should have the capability of performing MR guided biopsy. If this feature is not available with above diagnostic breast coil, an additional dedicated breast biopsy coil with minimum 8 channel should be provided.

8 Dedicated rigid shoulder coil, at least 16 channels - 1 Qty

9 Dedicated rigid knee coil, at least 16 channels - 1 Qty

10 Dedicated rigid foot-ankle coil, at least 8 channels - 1 Qty

11 Flex coils, at least 16 channels, each - 2 Qty

12 Vendor should offer multi coil acquisition in order to optimize increase and increased throughput FOV in their effective brochure/datasheet. Vendor should also send following information regarding each of the coil – Photo, Length width and height and weight (total weight) of coil, Number of Element, Number of Channel, FOV (actual and garunted) of each coil in super inferior – right to left and anterior to posterior coverage.

13 Please specify the total number of coils

F PATIENT TABLE – Please specify the type of table.

1 The table should be fully motorized. Computer controlled table movement in vertical and horizontal directions. Position accuracy should be +/- 1.0 mm or better. The longitudinal movement of table should be at least 190cm.

2 The table should have facility for manual traction In case of emergency.

3 The table should be able to withstand patient load minimum of 200 kgs.

4 Acoustic noise should be lowest possible and sufficient ear plugs should be provided.

5 The table should have patient auto alarm system.

6 The colour CCTV system with LCD display to observe the patient.

7 The table should deliver the protocols for automatic bolus chasing in peripheral angio with automatic table movement.

8 Two-way communications should be possible with the patient from the console room.

9 MR compatible audio system should be available both in the console and gantry room for patient comfort.

G COMPUTER SYSTEM IMAGE PROCESSOR / OPERATOR CONSOLE

1 Computer should be latest in the industry, fast and efficient. The configuration of the computers provided should be the latest with large 32 GB RAM and Memory capacity available at the time of delivery of the machine (2 lacs in 256X256 matrix) (Minimum 1TB hard disk).

2 Necessary image processor with large RAM for ultra-fast image reconstruction should be provided. It should be at least 8GB RAM. Please specify. RAM and reconstruction speed in images per second for full FOV 256 matrix. Higher will be preferred.

3 Computational Speed to match the single shot Echo Planar Imaging (EPI). Interactive angiogram, multi-planar three-dimensional (3D) reconstructions. Surface rendering, dynamic Imaging, vascular Imaging/angiography. Functional imaging, DTI.

4 The main host computer should have at least 19-inch Medical grade TFT/LCD type color monitor. If LED monitors are available at the time of machine delivery, it should be provided. At least 2mp

5 The main console should have facility for music system for the patient in the magnet room.

6 Filming and adequate storage for images and other applications.

7 Total hard disk memory to be sufficient to store at least 200,000 images of 256 x 256 matrix data size. Systems offering higher’ storage will be preferred. The system should have CD/DVD archiving facility on the main console and work station.

8 Dual DVD write/CD Read/Rewrite drive for writing of images, spectra and raw data along with the necessary software for reading the Images and spectra on DVD/CD storing capabilities. Provision for archival of k-space data and raw (unprocessed) images.

9 DICOM interface to hook DICOM dry/laser camera capable of storing printing 1024 x 1024 matrix size images at least in 16 formats without loss of digital resolution.

10 The system should be capable to connect to our existing PACS through HL7/RIS/HIS at no extra cost. Highest version of DICOM connectivity to be provided. It should have the capacity of plug and play. Interfacing with our existing PACS system will be vendors responsibility.

11 The image documentation should be possible from main console as well as from work station.

H “ADDITIONAL OEM WORKSTATION (3 QTY – 1 server, 2 clients to be deployed at ACTREC & 1 client to be extended to TMH, Parel)

1 The additional workstations (3)/Client server architecture (1 Server + 2 Clients at ACTREC + 1 client at TMH) with preferably the same user interface as of the main console with the ability of MPR MIP etc. It should have at least 19 inch medical gradeLCD / TFT or more colour monitor, with hard disc (specify the disc space and RAM). Minimum 1 concurrent user license for advanced post processing applications to be provided. Every client workstation to have basic visualization including MPR, curved MPR, MIP, miniIP, VRT.

Following Hardware specifications to be Included as standard:

I. Server (Qty: 1 ):

ii. 3 TB OPAL class 2.0 nvme ssd

iii. 10 TB HDD STORAGE

II. Client (Qty: 3 – Two clients to be deployed at ACTREC and ONE working Client to be extended at TMH, Parel which will offer same functions and post processing capabilities as available at ACTREC server client solution). The configuration of each client should be as follows:

i. 19” medical grade TFT/LCD display

ii. 31.5” IPS UHD 8MP Diagnostic monitor with auto luminance calibration and peak 450 nits brightness

iii. Gen 12 / 13, 8 core or better processor with base freq. of 2.8 Ghz

iv. Min.16 GB RAM

v. GPU with minimum 2 GB VRAM

vi. Optical Mouse

viii. Each OEM workstation should be supplied with Desktop computers for reporting. (Total - 05 nos of computers, each with 1TB NVME SSD and 1 TB SATA SSD, 32 GB RAM, i9 latest generation or higher processor, NVIDIA A1000 Graphics with 8GB Graphic VRAM or higher, 30 inch DICOM 2 mega pixel display - calibrated at backlight illuminance of 600 CD or more, OEM Keyboard and mouse)” OS: MS Windows 11 64-bit Pro MS Office perpetual latest version authentic

2 Work station/ Client should have a display of cardiac cine images in movie mode with rapid AVI creation.

3 Work station/ Client should have the availability of cardiac post processing capabilities; 1, calculation of ventricular area/Volume, Stroke volume, Ejection fraction, Relative Ejection Fraction, Calculation of Myocardiac thickness. Time volume diagram generation.

4 Image documentation should be possible from the main console as well as the workstation.

5 The perfusion analysis should have the capability to calculate the colour display of rel MTT, rel CBV, rel CBF. If the same not possible on main console, then workstation software having the same should be quoted.

6 Processing of 2D/3D CSI data with colour metabolite mapping,

7 Please mention if ASL technique for brain perfusion is available

8 The post processing workstation should have software package & volume rendering technique for analysis of the vessel disease with the possibility of detection of vessel segments and to quantify the changes in vessel size.

9 Volume Rendering Techniques software for visualization of complex anatomy.

10 DICOM: The Vendor should mandatorily provide the DICOM conformance statement along with the bid. Compatibility with data from other MRI system for post processing. Output in the form of jpeg, avi/equivalent formats should be possible.

11 Software license 3D surface rendering of ventricular regions

I Spectroscopy Evaluation

a Neuro Perfusion Evaluation

b One click perfusion analysis and processing

c T1 perfusion and Permeability(Ktrans, Kep, Ve, etc.)

d MR Subtraction

e Semiautomatic /automatic segmentation and volumes of whole brain and sub regions analysis

f Longitudinal Brain Imaging for assessing temporal trends of lesions

g DTI with tractography and simulation

h Fused display of segmentation, tractograms, BOLD data

i BOLD MRI analysis for block fMRI, and seed-based resting state analysis

j ASL analysis with correspondong color maps as overlay on anatomical images

k Simultaneous display of white matter tractography and skin, bone, brain parenchyma, tumour, artery, vein, and other regions.

l Stroke evaluation workflow

m Flow studies /Evaluation including MR CSF flowmetry

n Image Fusion like MRI-PET

o 3D mapping display of analysis results

p Volume measurement and display of the bull's eye for ventricle and myocardium

q Automatic extraction of the contours of ventricle and myocardium which are required for Measuring of various cardiac function evaluations including end-diastolic volume, end-systolic volume, end-diastolic ventricular index, end-systolic volume, end-diastolic ventricular index, end-systolic ventricular index, stroke volume, cardiac output, peak filling rate, time to peak filling, cardiac index, ejection fraction, body surface area, heart rate, and myocardial mass. Interactive tool for correction of segmentation

r Output cine movies

s Pre-rendering and automatic extraction of ventricular regions.

t 3D surface rendering of ventricular regions, saves to. stl format for 3D printing

u Non-rigid phase registration

v Display the long axis and short axis images of the heart

w Volume measurement and display of the bull's-eye for ventricle and myocardium

x Calculation of the ventricle capacity from a long axis image with the Area-Length method

y Assessment and review of myocardial tissue characteristics in multiple, user-defined, field-strength specific lookup tables

z Review of global and diffuse myocardial pathologies by means of T1 maps, T2 maps, and T2* maps

aa Map fitting/calculation of Molli analysis

ab Early and Late Gd enhancement analysis

ad Liver Dynamic

ae Automatic/Semiautomatic segmentation of liver tissues from MRI data (0 click segmentation of the healthy liver parenchyma)

af Semi-Automatic measurement of remaining and resected volumes and percentage

ag Volume calculations of liver, tumors, gallbladder and other regions

ah Extrusion of a path to add a missing branch of vascular structure

ai Fusion of ROIs from multi-phase series

aj Liver iron estimation (T2*, T1 mapping, T2mapping)

ak Automatic calculation of ADC map with DICOM push of the results to the PACS

al Fat fraction calculation including FF maps

am MRI Whole organ / single location perfusion analysis and maps including Ktrans, Kep, Ve, etc.

an Multimodality fusion

ao Breast Dynamic

ap Breast CAD/ DynaCAD for MR mammography

aq Structured reading display protocol for the localization and characterization of breast lesions

ar Silicone Breast Implant Display Protocol for the reading of silicone implant breast MRI exams

as Parametric analysis with AUC, Wash in wash out maps

at Dynamic time-intensity curve

au Breast Lesions localization in a diagram, Support display size and distance from the Nipple

av Dynamic acquisition (serial imaging) with capability to initiate scan sequences either from the magnet panel or from the console.

aw Dynamic acquisition and number of repeat scans with delay time either identical time interval or selectable.

ax Auto slices positioning from the localizer images by using latest AI based technique for Brain, Knee should be offered as standard.

ay Maximum -off center positioning both anterior-posterior and lateral direction and should be selectable.

az Gating: Physiological signals like ECG, pulse, respiratory, external signal

ba Triggering (interface for triggering input pulse from external source).

bb System should be capable of doing a free breathing scan including sensor /camera-based tracking.

bc The application software for image smoothing and edge sharpness etc. for in image resolution improvement should be quoted.

bd Artifact reduction/imaging enhancement/image filtering/image subtraction/addition multiplication/division techniques should be offered. Application of these techniques with Parallel Imaging is preferred.

be Flow 1st and 2nd order flow artifacts compensation.

bf Presentation slabs: a number of relocatable saturation bands to be placed either inside or outside the region of interest.

bg Fat saturation techniques: Frequency selective RF pulses to suppress fat signal in the measured image FOV.ROI selective (regional) fat suppression should also be given.

bh Magnetization transfer saturation; OFF resonance RF pulses to suppress signals from stationary tissue in FOV.

bi Phase contrast capability in 2D and 3D mode.

bj Image intensity correction.

bk Data acquisition in all three standard planes (axial, sagittal, coronal) and oblique and double oblique planes.

Higher matrix acquisition capability in single shot EPI, Acquisition time, TR TE and slice thickness should be clearly mentioned and supported by data sheet reference.

bl Structured reading display protocol for the localization and characterization of prostate lesions

1 Single and multi-shot EPI imaging techniques

2 Data acquisition in all three standard planes (axial, sagittal, coronal) and oblique and double oblique planes

3 Higher matrix acquisition capability in single shot EPI, Acquisition time, TR TE and slice thickness should be clearly mentioned and supported by data sheet reference

K APPLICATION SOFTWARE

1 System should have basic sequence package with spin Echo, Inversion recovery, Fast spin Echo and Gradient Echo with echo train length of 256 or more.

2 All necessary software and other associated post processing like MIP, MPR, and surface reconstruction including post- processing software for DTI should be provided. Additionally, work station should have post-processing software for analysing DWI, spectroscopy, perfusion, CSF flow data, T1 relaxation, T2 relaxation, T2star relaxation imaging data. System should be capable of having at least 128 directions DTI.

Perfusion software should have T2star, T1 perfusion and pulsed ASL capabilities.

Image fusion package for integration of MR images with CT planning and PET should be quoted. Image fusion package between DWI with T1W morphology should be quoted.

3 The main workstation should have display of cine images in movie mode with rapid arc creation.

4 Printing of films should be possible from both main console and main workstation.

5 Main Workstation should also be able to have the similar function and user interface as of the main console.

6 Latest software for high resolution, multishot, small FOV, diffusion imaging should be provided.

L IMAGING SEQUENCES

1 The system should be capable of selecting TR and TEs as per requirement in majority of the pulse sequences.

2 Spin echo (SE); multi-slice single echo, multi-slice multi- echo (8 echo or more) with minimum TR and TE. SE with symmetrical and asymmetrical echo intervals: MT-SE imaging sequence.

3 Inversion recovery (IR) including short TI, modified IRSE, FLAIR, DIR (Double Inversion Recovery), MT and FLAIR. Phase sensitive IR like true IR / real IR.

4 Gradient echo (GE) 3D gradient echo with shortest TR and TE, free choice of flip angle selection while maintaining SNR.

M FAST SEQUENCES & APPLICATIONS

1 Fast spin echo in 2D and 3D mode TI, T2 and PD contrast capable of acquiring maximum number of slices with a given TR a minimum TE. Echo train length should be at least 256 or more in fast spin echo mode.

2 Half Fourier acquisition capabilities should be available with/ without diffusion gradients and in combination with fast spin echo.

3 Fast inversion recovery with spin echo.

4 Fast gradient spin echo, IR multi-slice multi-echo mode with maximum turbo factor Sequences should incorporate RF focusing to acquire ultrafast gradient spin echo.

5 Fast gradient echo sequence should be provided to acquire images in ultra- fast 2D and 3D mode.

6 Fat and water suppressed imaging sequences including the sequence which should give 4 contrast (in phase, opposed phase, FAT and Water) images in a single acquisition to be quoted as standard. [Fat suppression Techniques like STIR, Spectral fat saturation, SPAIR, Water Excitation should be quoted as standard] Dixon method to be quoted as standard / 2-point Dixon and 3-point Dixon method

7 EPI optimized sequences for T1, T2, PD imaging. Perfusion, regular diffusion values {minimum 300b, max 10000b, 3 directions), EPI-FLAIR. CPI-IR, IPI- FLAIR diffusion tensor. EPl- MT-FLAIR, tensor diffusion (max 10000b values in minimum in six directions) for diffusion studies. Suitable artifact/fat suppression techniques to be incorporated in the sequence to have optimum image quality. There should be capability of generation of ADC map (isotropic and anisotropy from the regular diffusion and tensor data). Facility of online generation of ADC/trace/FA map should be there. Offline generation of multiple b-values from a single Diffusion Scan is preferred.

8 Optimized sequence package for special applications.

9 SWI like SWI/SWIp/Eswan 2.0 should be coated as standard. Mention slice

10 Dynamic Liver imaging sequences like Dynavibe/thrive/lavaXV thickness, area cover and time taken.

11 Fast dynamic 3D breast imaging like views/bliss/vibrant XV should be quoted as standard

12 For Imaging of internal ear, True FISP Dual excitation like CISS/ Fiesta c should be quoted as standard.

13 3D high resolution T2WI – possibility to reformate data in all sequences – Double echo study state for ortho/knee imaging.

14 For Brainstem imaging Multi echo data image combination like MEDIC / MERGE / mFFE .

15 T1Weighted STIR, T1 weighted FLAIR should be quoted as standard.

16 Double Echo steady state like DESS/Proset should be quoted as standard. Magnetization

17 MR angio; 2D/3D TOF, 2D/3D Phase contrast (with and without gating) transfer saturation, TONE, CEMRA, black angiography for cerebral, pulmonary, abdominal and peripheral vessels. For peripheral angio, moving table angiography should be offered so that complete limb can be examined in one go. Bolus tracking software package should be offered. Sequences for breath hold angiography with contrast enhancement should also be offered. Kindly mention coils used for it.

18 Renal, abdominal, Pulmonary 2D / 3D MRA sequence including single breath hold sequence. Contrast MR enhanced

19 Dynamic angiography with K space Manipulation like TWIST/TRICKSXV/4D TRAK should be possible.

20 NON-Contrast MR Angiography like Native/ Inhance/ Trance for whole body applications to be quoted as standard.

21 The system should have the Hydrogen, Single Voxel spectroscopy, Multivoxel multislice 2D, 3D spectroscopy, Spectroscopy and also the Chemical shift imaging in 2D and /3D even in oblique angles. The complete processing / post – processing software including colour metabolite maps should be available. Mentioned detail about Brain, prostate (3D CSI / Prose), spectroscopy. breast (GRACE/BRACE)

22 Basic cardiac sequences which includes, (a) MR cardiology package for evaluation of heart in long and short axis with black blood cardiac imaging (b) package for – prospective and retrospective gating, etc.

23 Diffusion weighted imaging, with b value range of 300 to 10,000 or above with a facility to generate the ADC map with the acquired b value. The system should have facility for online automatic generation of ADC maps. Please specify the motion correction algorithm/package for high-resolution motion free diffusion weighted imaging with multishot/ segmental EPI, techniques. It should be possible to have FLAIR diffusion with generation of corresponding ADC maps. Sequence package for diffusion study in organs like brain, kidney, liver, muscle, heart, etc. High b value DWI must be fused T1 morphology as a standard for visualization of tumour activityThe system should have facility to do Head to Toe imaging without shifting the patient /repositioning the coil for an average built young Indian adult at one go for metastases study and without any loss of SNR. Whole body diffusion, whole body STIR Imaging for metastatic evaluation and systemic disease. Specify the method of doing it [Local coils or Body coil used, Number of station, Number of local coil used and their name and number, Table travel etc.]. Length of whole body scanning in cm. Time taken to complete whole body head to toe diffusion imaging and PET like MR imaging in Onco application.

24 Perfusion imaging to enable large anatomy coverage of the brain and in the calculation of the resulting hemodynamic as well as physiological parameters. Perfusion study in organ systems like kidney, brain, heart etc. Perfusion study with single shot EPI with automatic Processing. Evaluation package for calculating rCBV, rCBF, rMTT, perfusion map, Time to Peak Map etc.

25 Flow quantification in vessels, hepatobiliary system.

26 Flow quantification package for CSF flow data with dynamic CSF flow imaging, aqueduct and spinal canal.

27 Free breathing body imaging sequences including angiogram should be quoted as standard. Motion insensitive sequence that allows abdominal, head, head neck, spinal, thoracic and pelvic imaging in free breathing mode, providing a solution for patients without breath hold capabilities should be also offered.

28 3D Turbo spin echo with variable flip angle acquisitions like CUBE, SPACE, 4D VISTA/ drive to be quoted as standard. Please mention whether it is available with Parallel Imaging technique for whole Body.

29 MR Cholangiography and Pancreatogram: Specialized sequences and processing to perform MRCP. MR Colonography.

30 MR ventriculography and cisternography, Myelography and MR Neurography

31 Parallel acquisition technique such as SENSE, SMASH, ASSET, IPAT, ARC and other new sequences to be quoted as standard.

32 Specify the factor by which the acquisition time is reduced for similar acquisition with and without parallel imaging. A scan time reduction factor of 8 for head, body, cardiac, angio and ortho application is required.

33 The system should perform DTI at least in 128 directions with possibility of processing with depiction of fractional anisotropy, mean diffusivity and other DTI metrics. Provide the fiber tracking software with overlays on various conventional imaging. Diffusion tensor imaging package also should be included as standard. Provide Fibre Tracking Software with overlays on various conventional images on 3D.

34 In-line motion correction for uncooperative’ patients/paediatric applications, that is motions/patient movement correction sequences and algorithms (not just faster scanning or parallel imaging techniques) for non-cooperative/sick patients/children should be provided.

35 3D High resolution imaging for inner ear

36 Most advanced and recent Multislice excitation technique like Simultaneous Multislice or Multiband should be offered as standard

37 Synthetic MRI with myelin Estimation

38 Whole body diffusion in coronal plane

39 Neuro fusion software- for BOLD and DTI and tumor

40 Susceptibility Weighted Imaging (SWI)

41 4D Multiphase HD Dynamic Contrast enhanced Imaging - DISCO / TWIST VIBE (Syngo Freezit)

42 Breast Dynamic Imaging and CAD system

43 FAT Fraction & Iron Overload - IDEAL IQ / mDixon Fat Quant / LIVER LAB

44 2D Selective RF Excitation - High resolution & small Field of View - FOCUS Diffusion / IRIS Zoom

45 Synthetic DWI for generation variable B-Value images

46 Compressed Sensing - Hyper Sense / Compress SENSE / Compressed Sense across all anatomical sites. Artificial Intelligence Sequence & Deep Learning Algorithm like Deep Resolve Pro Package & SWIFT Brain, AIR Recon DL, SMARTSPEED Precise should be offered for Brain, Spine, MSK , Body & DWI sequences.

47 Simultaneous MultiSlice - Hyper Band / Multi band SENSE / SMS

48 Tailored 3D Imaging- 3D Imaging for all sequences for all anatomies, compatible with parallel imaging

49 MR Neurography -3D

N Kindly mention softwares for correction of following artifacts.

1 Ghosts / Motion Artifacts

2 Aliasing / Wraparound

3 Chemical shift related artifacts

4 Truncation Artifact

5 Magnetic Susceptibility Artifact

6 Straight Lines and zipper artifacts

7 Shading artifacts

8 Parallel Imaging Artifact, Cross excitation and cross talk

9 Latest software for removal of metal artifact like advance WARP/ OMAR/ MAVRIC-SL. Please mention whether it is available with Parallel Imaging technique.

10 Sequences for MR guided Intervention

11 Balanced steady-state free precession acquisitions (bSSFP)

12 Ultrafast T2 weighted sequence - HASTE (half Fourier acquisition single shot turbo spin echo) or equivalent

13 T1 Fast Spin Echo / Turbo Spin Echo sequence

14 T1 Volumetric Interpolated Breath-hold Examination (VIBE)

15 Fusion software for multiple modality like Nuclear Medicine, MRI, CT or DSA

16 MRI guided Breast biopsies. If Biopsy is not possible on 15 channel coil (as mentioned in point number XII -E-7) then provide an additional dedicated breast coil for biopsy with minimum 4 channel.

O POST PROCESSING AND EVALUATION

1 3D Multiplanar reconstruction (MPR) in any arbitrary plane including curved planes with freely selectable slice thickness and slice Increments.

2 3D Surface reconstruction, volume rendering and evaluation on reconstructed images with minimum time.

3 MIP in 2D and 3D mode, targeted/segmented MIP in any orthogonal axis with minimum processing time and capable of displaying in cine mode.

4 Basic cardiac evaluation should be quoted as standard. Kindly specify it.

5 Evaluation and display of diffusion images.

6 Full Perfusion imaging (brain, body and cardiac) with necessary post processing with time intensity graph and other statistical parameters. System should be capable of all types of perfusion sequences (contrast and non-contrast) and post-processing including DSC, DCE and 3D ASL imaging.

7 Flow quantification and evaluation for vascular (high and low). CSF bladder outlet and cine display.

8 Image statistics: Measurement of distance, area, volume (2D and 3D), angle, SD, mean, image addition, subtraction, multiplication, division, interpolation, segmental, threshold, histogram (ROC) should be possible.

9 Evaluation features like zoom, rotation, scroll, image synthesis, multi point T1 and T2 calculation (more than 8) window searching, text dialogues graphics. Sorting, searching, archiving, recalling, etc.

P Functional MRI (LCD based technique)

1 Software for advance brain imaging (motor, speech, visual and auditing etc. paradigms)

2 Advanced functional brain imaging generating hardware (motor, speech, visual and auditing etc. paradigms)

3 Super imposition of functional imaging along with T1, T2 imaging

4 Resting state MRI to be given as standard along with post processing application

XIII STANDARD ACCESSORIES AND EQUIPMENT

A TECHNICAL SPECIFICATIONS for "MRI COMPATIBLE DUAL HEAD INJECTOR" -QTY 01 WITH EACH

1 Specify the make and model

2 Flow Rate A-SIDE- 60 ml syringes, 0.1-10.0 ml/sec

3 B-SIDE-60 ml syringes, 0.1-8.0 ml/sec

4 Pressure Limit-150 peak psi

5 Syringe Sizes-60ml empty syringes,10,15,20,30 ml prefilled syringes

6 Volume A-SIDE-10,15,20,30 ml

7 Volume B-SIDE-50,60,125 ml

8 Scan Delay-0-60 seconds

9 Phase Delay-0-600 seconds + pause

10 Number of Phases-6 including timing bolus

11 Protocol Memory-40 protocols

12 Inject Results-Last 48 injected protocols

13 1000 compatible syringes compatible to the equipment to be supplied

B MR elastography hardware and compatible software should be supplied - 1 Qty.

C FERROMAGNETIC DETECTION SYSTEM FOR IMPLANT DETECTION Qty - 01 WITH EACH

1 Specify the make and model

2 For detection of small ferromagnetic objects and implants inside the patients.

3 Should have fluxgate sensors to detect small ferro magnetic objects both on and implants inside the body of the patients.

4 The equipment should be compact, wall mounted, easy to use and should not weight more than 6 kgs.

5 Should provide detection for minimal detectable signal of 80p Tesla/0.8 micro Gauss.

6 Should be able to scan full body and should avoid any invasive detection procedure.

7 The equipment should be entirely passive and should be safe for use in all types of patients including patients with implants.

8 The equipment should be ideal for use of non-ambulatory patients as well.

9 The machine should integrate into current screening procedures of the hospital without changes to existing workflow

10 Should have control to prevent unwanted alerts being triggered by passing personnel

D WALK THROUGH FERROMAGNETIC DETECTOR SYSTEM -QTY 01 WITH EACH

1 Specify make and model

2 Walkthrough ferrous detector with multiple sensor to help detect approaching ferro magnetic hazards and with door ignore function to be installed at entry door of MRI Scanner Room (Zone III type). It should have continuous detection without breaks and continuous audio and video recording for alarms triggered.

3 Fluxgate Detector system wall-mounted immediately outside the MRI room door/doorway ( in zone 3 ) . Must not be installed on or inside the MRI door, within Zone 4 as this provides no warning of approaching risk items until the door is opened, and detection only occurs within Zone IV.

4 System should work with either inswing or outswing doors.

5 System should be equipped with continuous recording of the video for alarms triggered.

6 System should be designed to be capable of distinguishing between approaching ferromagnetic risk item and the magnetic field resulting from MRI door movement when being opened or closed; resulting in reduced extraneous audible alarms

7 System should have Fluxgate detection system which provides maximum reliability and consistency of detection.

8 System should have a detection system to provide continuous detection and alert capability. Must not allow any breaks in detection or alert capability following MRI door opening, or following preceding alert.

9 2 stage alert system: System should give visual alarm for approaching risk items in advance of them reaching the threshold followed by an audio alarm in case when the ferrous item tries to cross Zone 4 threshold.

10 Does not give a false alarm for ferromagnetic items objects moving out of the MRI Scanner room.

11 The system should be entirely passive only; should not emit any magnetic field.

12 Should allow passage of patient trolley.

E MR compatible Trolley & Wheel chair with each MR system

1 Specify make and model

2 MRI compatible trolleys (Qty - 2) and MRI compatible wheel chair (Qty - 1) should be provided to transfer patient in and out of gantry room. Mention the make and model of trolley and wheel chair. RF Cage/cabin should include ceiling, flooring, side panelling, lighting with AC diffusers and medical gas line as standard to be done by company. RF cage/cabin of appropriate size should be provided / done by the vendor as standard. It should not form a part of Turnkey job. Furniture interior to gantry room should be provided by Vendor. Provide the furniture required for keeping various coils, equipment, and furniture related to patient comfort in the gantry room.

F Colour Laser printer with each system - 1 Qty.

1 A colour laser printer for printing high-resolution color-coded 3D images and protocols on plane in 600 dpi resolution and more than 20 ppm.

G Disposable Ear pads and ear plugs to reduce noise while imaging in children and adult- 1000 Nos.( With each system )

H Furniture - coil rack inside gantry room, table for console .

I Additional dockable table or trolley with table top should be offered with each system

J MRI compatible Laryngoscope set (6 blades + 1 Handle + 1 Battery) - 2 Qtys ( With each system )

K MRI Compatible Suction Apparatus - 1 Qty ( With each system )

L MRI Compatible Infusion Pump with Crash cart - 1 Qty ( With each system )

M MRI Compatible Syringe pump Crash Cart- 1 Qty ( With each system )

N MRI Compatible Stethoscope - 1 Qty ( With each system )

O MRI Compatible Crash Cart - 1 Qty ( With each system )

P Disposable Ear pads and ear plugs to reduce noise while imaging in children and adult- 1000 Nos. ( With each system )

Q Future updates of software should be provided by vendor at no extra cost during warranty and CMC.

R Furniture - coil rack inside gantry room - 2 Qty with each system table for consol.

S Ambient Experience / In bore experience for patient comfort

XIV Other requirements

1 The vendors should inspect the site before quoting and ensure that the unit and all accessories can be installed in the available space without any functional compromise.

2 Main Equipment,UPS and Accessories/ Additional support equipments should comply to National/ International Quality and safety standards like USFDA /European CE/ ICMED/BIS approved product.

3 Electrical safety conforms to standards for electrical safety IEC-60601 / IS-13450

4 Onsite training of two months should be provided by the vendor to the technician.

5 Service training to be provided to Biomedical Engineers.

6 Live Demonstration of the equipment is required.

7 Service tool kit hardware & software should be kept onsite to ensure minimum down time

8 All the software related licence, keys to the system should be handed over to USER.

9 Please provide a list of installations of the quoted model.

10 Should provide high resolution CCTV Camera system - 6 Qty capable of 24/7 monitoring and recording for machine room and console room(The location of cameras will be identified at the time of turnkey)

11 Should provide 55" Full HD High resolution display for Camera System. - 1 Qty with each system

12 For CCTV Camera system the supplier shall provide drawings containing complete details of wiring, cable routing and all necessary documents before the installation for the approval. The final documents as required by the user shall be submitted after the installation is completed.

13 All the necessary accessories like screws, pegs, ferrules, bends, clamps, reinforced Flexible Conduits, Rj-45 Connectors, Cable tags, CCTV sign Boards, cable Glands, clips for PVC pipe fitting etc or any accessory required for installation shall be in the scope of supplier without any additional cost.

14 Please submit the floor plan for installation and commission.

15 Online Remote access for technical support should be Provided.

16 Must provide online UPS with isolation transformer (1 Qty) with each system of adequte capacity for the complete systems. With minimum 15 minutes back up. SNMP card should be provided with the UPS as a standard. SNMP card should have a facility remotely examine/access the battery charge levels , input & output voltage , frequency, temperature ,alerts,alarms and other characteristics .

17 Performance certificate from five govermrnt institutes is mandatory.

18 Please specify pre installation requirements (electrical, HVAC etc.)

19 Please specify footprint size & weight.

20 Please specify power consumption.

21 All Necessary standards and norms. (As applicable).

22 All documents like Service Manual, User Manual, technical data operational manual, log book, certificate of calibration & inspection from factory should be provided by the company.

23 Certificate of calibration and inspection from factory.

24 Log book with instruction for daily, weekly, monthly and quarterly maintenance checklist.

25 That the vendor should also provide all the latest softwares and facilities for that particular system, that they will be exhibiting in the RSNA conference of the year of installation. In addition please note that the equipment to be supplied should be latest equipment satisfying the tender specifications and any software up gradations during the period of warranty and CMC period is to be covered.

26 No. of similar models: India / World (enclose list of institutions)

27 No. of installation: Contact details of the end user need to be provided.

28 No. of certified engineers in India (enclose list of names)

29 Remote Diagnosis Facility (India / Abroad) availability

30 30(a). MRI-Compatible Fire Extinguisher to be provided: - 02 Quantity (One in Magnet room and one in console area). Also, refilling, maintenance, and repair of fire extinguishers should be done under warranty and CMC.

30.(b). There should be two quench switches one in the console room and one magnet room. Also, the MRI quench outlet should be above the roof height.

30(c). MRI-compatible NOVEC Fire suppression system should be provided for the magnet room, equipment room and console area

XV MR Compatible Multi-Para Hemodynamic Monitor-1 No. with each system

1 The monitor and listed accessories must be CE /FDA/BIS/ICMED approved. Monitor should comply with electromagnetic immunity requirements of standard IEC 60601 – 1 – 2. Should be high end MRI compatible patient monitoring system for monitoring all vital parameters of the patient in MR room & should be compatible with MRI scanner up to 3 Tesla. Display: Should have 12" - 15” colour TFT/LCD display with high resolution. Should be able to display at least 5 waveforms and all related numerical values. Monitor should be both mains as well as battery operated. - Should have internal rechargeable battery with backup operation minimum 6-8 hours. -The battery charger should be MR compatible and allow placement in the MR scanner room. Monitor should be able to monitor Electrocardiogram (ECG), pulse oximetry (SpO2), Non-invasive blood pressure, Capnometry (ETCO2 monitoring), Invasive pressure (IBP), Anaesthesia gas monitoring, temperature and recorder. Should have wireless ECG and SpO2 modules with ability to monitor continuously for 6-8 hours. A magnetic trolley with accessory storage (from the same manufacturer). Should be able to store and view at least 8 hrs. of graphical and tabular trends for all the parameters; with the option for selecting the intervals for storing the trends. Should have facility for at least 10” screen wireless Slave Monitor for remote display. Weight of the monitor should not be more than 40 kgs.

2 The scope of supply should include MRI compatible accessories with each system: ECG Cable – 2, Spo2 Probe: SpO2 finger probe (adult) – 2 nos, Peadiatric- 2nos, Neonate-2nos, Ear Lobe - 2 Nos., NIBP hose tubing – 2 no, NIBP Cuff : Adult(25-35cm), Paediatric(18-26cm) and neonatal (6-11cm), Thigh (46-66Cm) NIBP cuff - 2 nos., IBP cable with Transducer - 4 nos, SkinTemperature sensor - 2 nos, Disposable ECG electrodes (adult) – 2 set, Disposable IBP kit - 2 set, Essential accessory for ETCo2 Monitoring – 2 set, AGM sample Line- 10 Nos., A magnetic trolley with accessory storage (from the same manufacturer) – 1, Power pack and mains cable – 1 each, Operating Manual – English, Slave monitor with power adaptor and cord - 1no, - Charging Station and standby battery for each modules should be provided with each Monitor - 1 Set/ Nos. Should perform yearly calibration and preventive maintenance (2nos) during warranty & CMC (which will include spare replacement, consumable spares, breakdown calls) Testing & measuring equipment used should be traceable to SI units through National/international standards( As per NABL norms). To submit SOPs for PMS at the time of installation/commissioning. Performance certificates of IQ, OQ, PQ tests to be submitted at the time of installation/commissioning; if desired by the end user Please submit the technical data sheet along with the brochure as a tender document with reference to the quoted make & model. Please specify footprint size & weight. Demo of the quoted model, will be required if so desired by the user, after the opening of the technical bid and prior to opening of financial bid. This is for technical evaluation. Please visit the site to check whether quoted model can be accommodated in the available space. Please specify power consumption.

XVI STANDARDS AND SERVICE SUPPORT

A User's list: A list of installations with the address and contact numbers to be provided. (User list should be for the quoted model)

B After Sales Service Support.

C Complete operational manuals and technical information should be provided. Company should provide technical support for hardware and software, spares and consumables. Company should provide required spares and consumables for at least 7 years even after discontinuation of the model. Bidders who do not qualify this criterion shall not be considered. Bidder should provide address of the authorized service centre and details of number of personnel with training credentials. Response Time: Should be within 6 hrs from lodging a breakdown complaint on toll free or by email

D Unpacking and Shifting the consignment to the installation site is to be included in the scope of supply. Bidder/manufacturer/authorized service provider should take responsibility to lift/shift the consignment from unloading site to the installation site . Unloading site shall be "Stores Department, KS Building, ACTREC Campus or an area allocated by them". If needed, Bidder has to arrange for the labourers at no charge to ACTREC. (Before submitting the quotation, bidders may visit ACTREC to know unloading site and installation site)

E Installation,Commissioning and Training is included in the scope of supply. Bidder, Manufacturer and/or its authorized representative should undertake installation and commissioning of the equipment.

F Local Service Support: Should have local office and service support/service engineer for attending the breakdown calls, please provide the address along with list of engineers, their lacation and contact details in India.

G Response Time: Should be within 6 hrs from lodging a breakdown complaint on toll free or by email.

XVIII Warranty and CMC

A Warranty : 2 Years comprehensive-on site- factory warranty for the entire equipment system. All third party and bought out items, accessories, attachment, software etc. integrated with the system should also be covered by 2 years factory warranty from respective manufacturers. The vendor should perform 4 nos. of preventive maintenance services/ year, all breakdown visits Helium refill and QA/QC as per prescribed protocol during the warranty period.

B Comprehensive Maintanence contract (CMC): Vendor to qoute for CMC for 8 years post 2 yeas warranty. CMC should cover the entire MRI system and will included 4 preventive maintenance/ year, all breakdown visits and periodic Helium refill as well as helium refill in case of MRI quench . CMC will cover the equipment, hardware, software, third party supplies and all bought out items used/ supplied with the system. CMC should also include software upgrades / update cost, no separate software licence fees will be payable. CMC should also cover periodic QA QC as per prescribed protocol. Year-wise break up to be furnished.Planned preventive maintenance and other planned maintenace activity should be done on Public Holdays and on Sundays.

22 Penalty Clause:

a The supplier and / or its Indian agent will be required to maintain the equipment and all its bought out items (including software updates and various licenses) used for the functionality of the system in good working condition during the warranty/ CMC period with 96% uptime guarantee.

b Equipment shall be fully functional to be considered as the uptime. In case of partial functionality, the proportion of functionality shall be determined and downtime shall be adjusted by such proportion (i.e. if the equipment is 70% functional, 30% downtime shall be applicable). In cases where it is not possible to definitely determine the proportion of functionality, the downtime shall be considered as 100%.

c The decision of the TMC management or its representative in determining the % of the downtime shall be final and binding.

d Essential period to shut down the equipment entirely or partially during warranty/CMC period shall also be included in the downtime while calculating the guaranteed uptime i.e. all features as per specifications in purchase order should be functional for uptime.

e The penalty applicable for downtime shall be calculated on an hourly basis and will be at the rate of 0.004% per hour (0.1% per day) of the total cost of the equipment (excluding works), during and up to the period of warranty/ CMC. There shall be a permissible down time of 360 hours per year, beyond which the down time penalty will be applicable.

f However, in case of the downtime exceeding seven days (i.e. 168 hrs) at a stretch, the downtime beyond these 168 hours will be considered for calculation of downtime penalty.

g The levy of this penalty shall be at the discretion of director TMC irrespective of the overall up time of the equipment throughout the period of the warranty or CMC.

h This clause is to ensure maximum uninterrupted service to patients and hence Director, TMC’s decision in enforcing / invoking this clause will be final and binding for all.

i For CMC, W.O. issued by TMC shall be final as per D.A.E. Norms. TMC & its units shall not sign separate legal contract as per vendor’s format.

XIX Important terms to be noted by the bidders:

A Read the above scope of supply carefully and quote accordingly. Incomplete and /or partially complete offers are liable to be rejected.

B Manufacturer/bidder should clearly indicate typical life span / Life expectancy of the quoted equipment.

C Item/Equipment quoted should not be a second hand/refurbished/on verge of obsolescence/outdated model. Similarly, after award of contract, the item supplied should be a newly manufactured item .

D After opening of the Technical bid (Part-1), Physical demonstration of the quoted model may have to be shown / arranged by the bidder, if requested by the Institute. Physical demonstration may be shown at one of the end user’s site/Principle company’s application lab/manufacturing site located in Mumbai/Navi Mumbai/Thane cities within 10 days from the date of request. Physical Demonstration may be requested to confirm the availability of any or all technical features as mentioned/stated in the technical bid. Physical Demonstration will also be a part of technical evaluation process. If the bidder does not comply, such bids are liable to be disqualified. (Demonstration of quoted model is to be shown and not the demonstration of similar models with different technical specifications and features)

E Past experience of the bidders in terms of quality of supplied equipments, after sales service and application support will be taken into consideration while technical evaluation.. Bidders who has unsatisfactory past experience in any of the TMC/DAE unit last 2-3 years, in terms of quality of supplied equipments, after sales service and application support, bids of such bidders may liable to be rejected.

F Complete and detailed information should be provided in respect to each point specified in the specifications. Technical bids that are incomplete in any respect are liable to be rejected. Provide relevant supportive information, publications, catalogue, etc. Bidders providing misleading or wrong information are liable to be rejected. All technical claims should be printed in the technical brochure of the equipment.

G If any contradictory statements /figures/information is observed in the compliance chart and in the technical bid, then the technical information mentioned in the product literature/brochure will be considered true and further evaluation will be done based on the information given in the product literature/brochure. Regarding the warranty and CMC terms, information quoted in the technical bid will only be taken as valid terms.

H Compliance column may be filled with relevant data, figures, range etc. as applicable. Do not just mention "YES / NO / Complied ".

XX Declaration by the bidder

A We have quoted for all the items meeting the description/scope of supply in the Financial bid as per prescribed format of the Tender documents and we agree that Partial/incomplete offers are liable for rejection.

XXI L1 Calculation:

A L1 will be based on cost of the entire system including accessories and other support eqipment at landing cost at ACTREC ie. Equipment cost, applicable taxes and duties, transportation & insurance charges, installation charges along with 2 years warranty cost + 8 years CMC cost including accessories and other support eqipment at landing cost at ACTREC ie. Equipment cost

Note: Payment will be made by the ICICI Foundation.