Consultancy services to carry out Non-GLP Determining if the Compound-1348 is a Substrate of the Transporters 1. P-gp 2.BCRP along with 3.Permeability assessment using Caco2 assay system

Non-GLP Determining if the Compound-1348 is a Substrate of the Transporters (i) P-gp, (ii) BCRP along with it’s (iii) Permeability assessment using Caco2 assay system [n=3, using standard compounds, substrates and inhibitors] Note 1: n=3 or triplicate well [Apical to Basal and Basal to Apical permeability] Note 2: Use at least three standard compounds covering low to high permeability Note 3: Standard Substrate at least one each for P-gp and BCRP Note 4: Standard Inhibitor at least one each for P-gp and BCRP Note 5: Membrane integrity test should be performed Note 6: Data type: Papp value, % Recovery, permeability rank, efflux ratio, efflux ratio in presence and absence of inhibitor, etc

Anthem Biosciences Private Limited (BID ID -794173)