Supply of Molecular Diagnostic Kit

Amount

Molecular Diagnostic Kit

EGFR Mutation Analysis Kit (Performance certificate for timely supply) 1) IVD Certified 2) Should detect all clinically relavant mutation in Exon 18,19,20 and 21 3) Compactable to Real Time PCR-ABI 7500 DX 4) Sensitivity and specificity should be mentioned 5) Kit should work with FFPE samples 6) If requested on site demo with 5 sample should be performed 7) List of mutations which can be detected should be mention 8) User list of 3 hospital or medical institute should be provided 9) On site technical team support should be given on request

JAK 2 Kit 1. IVD Certified 2. Should detect V617F and exon 12 mutation 3. Compactable to Real Time PCR-ABI 7500 DX 4. Sensitivity and specificity should be mentioned 5. Kit should work with blood DNA 6. If requested on site demo with 5 sample should be performed 7. List of mutations which can be detected should be mention 8. User list of 3 hospital or medical institute should be provided 9. On site technical team support should be given on request

FLT3 ITD Kit 1. IVD/CE Certified 2. Should detect internal tandem duplication(ITD) mutations and tyrosine kinase domain (TKD) mutations D835 & E836 3. Compactable to Real Time PCR-ABI 7500 DX or gel based 4. Sensitivity and specificity should be mentioned 5. Kit should work with blood DNA 6. If requested on site demo with 5 sample should be performed 7. List of mutations which can be detected should be mention 8. User list of 3 hospital or medical institute should be provided 9. On site technical team support should be given on request

BCR-ABL Quantization kit 1. IVD Certified 2. Should detect in IS scale 3. Compactable to Real Time PCR-ABI 7500 DX 4. or more point standard for Abl and BCR-Abl should be provided 5. Sensitivity and specificity should be mentioned 6. Reference RNA should be provided (for 15 runs)- May be supplied in batches. 7. If requested on site demo with 5 sample should be performed 8. List of fussion which can be detected should be mention(fussion) 9. User list of 3 hospital or medical institute should be provided 10. On site technical team support should be given on request

PML-RAra Kit 1. Should detect BCR1,BCR2 and BCR3 Type 2. Compactable to Real Time PCR-ABI 7500 DX or gel based. 4. Should perform qualitative detection 5. Sensitivity and specificity should be mentioned 6. If requested on site demo with 5 sample should be performed 7. User list of 3 hospital or medical institute should be provided 8. On site technical team support should be given on request

FFPE DNA Isolation kit 1. User list has to provided 2. On site demo for 5 sample has to be provided 3. Kit should be coloum based 4. Optimum required FFPE sample should be mentioned 5. Optimum yield should be mentioned 6. During onsite demo quality and quantity of isolate will be evaluated

BLOOD DNA Isolation kit 1. User list has to provided 2. On site demo for 5 sample has to be provided 3. Kit should be coloum based 4. Optimum required blood sample should be mentioned 5. Optimum yield should be mentioned 6. During onsite demo quality and quantity of isolate will be evaluated

FFPE DNA Isolation Kit

Leukemia Panel for following(PCR Based) 1. Should detected following - AML1 - ETO - CBFB – MYH -MLL – AF4 - TEL- AML1 - E2A – PBX - PML – RARa - Should compatible for 7500DX or gel based

MNN Panel Should detect following - BCR-ABL - CALR – Type I & Type II - MPL Mutation – 515 & 505 - JAK2 V617 F - Should compatible for 7500DX or gel based

IDH I & IDH II Should detect following - R132H - R132C For IDH I - R100Q - R132X - R172K - R140X IDH II - R172X - Should compatible for 7500DX or gel based

KRAS & NRAS PANEL Should detect mutation in following codones Codon 12 13, 61, 117, 143  Should compatible for 7500DX or gel based

BRAF Analysis Codon 600 Should compatible for 7500DX or gel based

ALK ROS PANEL  ALK / Rearrangement  ROS / Rearrangement - Should compatible for 7500DX or gel based

AML Panel - CBFB-MYH11 - BCR-Abl - PML-RARa - AML-ETO - c-KIT - NPM1 - FLT3 KTD - FLT-ITD - Or more markers - Should compatible for 7500DX or gel based

ALL Panel - E2A-PBX1 - TEL-AML1 - MLL-AF4 - MLL-ENL - BCR-Abl - Or more markers Should compatible for 7500DX or gel

Immunoglobin (IgH) rearrangement analysis kit Should compatible for 7500DX or gel based

Thrombosis SNP Panel Assay - Factor II - G20210 - A Factor V - H1299R - Factor V - R506Q - Factor V - Y1702C - MTHFR - A1298C - MTHFR - C677T Should compatible for 7500DX or gel based

Circulating DNA isolation kit

DPYD gene polymorphisms DPYD*2A (IVS14+1G>A, c.1905+1G>A, rs3918290), DPYD*13 (c.1679T>G, rs55886062), DPYD D949V (c.2846A>T, rs67376798) and DPYD IVS10 (c.1129–5923C>G, rs75017182), Should compatible for 7500DX or gel based

UGT1A1 gene polymorphisms UGT1A1*1 (TA)6, UGT1A1*28 (TA)7, UGT1A1*36 (TA)5 and UGT1A1*37 (TA)8, Should compatible for 7500DX or gel based

RET rearrangement Should compatible for 7500DX or gel based

MYLAB DISCOVERY SOLUTIONS PRIVATE LIMITED

J D DIAGNOSTICS PVT LTD

Biowel Inc